Case Studies

Chapter 2: Infection
Case 2.1 Infectious mononucleosis
Case 2.2 Recurrent herpes zoster
Case 2.3 Chronic fatigue syndrome
Case 2.4 Acute bacterial tonsillitis
Case 2.5 Streptococcal toxic shock syndrome
Case 2.6 Rheumatic heart disease
Case 2.7 Tuberculosis
Case 2.8 Acute vulvo-vaginitis
Case 2.9 Cerebral malaria
Case 2.10 Schistosomiasis

Chapter 3: Immunodeficiency
Case 3.1 X-linked agammaglobulinaemia (Bruton's disease)
Case 3.2 CD40 ligand deficiency
Case 3.3 Common variable immunodeficiency disorders [CVID]
Case 3.4 IgA and IgG subclass deficiencies
Case 3.5 Severe combined immunodeficiency
Case 3.6 IRAK 4 deficiency
Case 3.7 Chronic granulomatous disease
Case 3.8 IL-12 receptor deficiency
Case 3.9 Isolated deficiency of complement component
Case 3.10 Acquired immune deficiency syndrome: Kaposi’s sarcoma
Case 3.11 Acquired immune deficiency syndrome: persistent generalized lymphadenopathy
Case 3.12 Listeria monocytogenes meningitis after immunosuppression for SLE

Chapter 4: Anaphylaxis and Allergy
Case 4.1 Wasp venom anaphylaxis
Case 4.2 Latex-induced anaphylaxis
Case 4.3 Drug-induced reaction
Case 4.4 Seasonal allergic conjunctivitis
Case 4.5 Perennial allergic rhinitis
Case 4.6 Allergic asthma
Case 4.7 Oral allergy syndrome
Case 4.8 Cow's milk allergy
Case 4.9 Nut allergy
Case 4.10 Is this food allergy?
Case 4.11 Chronic urticaria and angioedema
Case 4.12 Atopic eczema

Chapter 5: Autoimmunity
Case 5.1 Is this rheumatoid arthritis?
Case 5.2 Myasthenia gravis and neonatal myasthenia gravis
Case 5.3 Primary autoimmune hypothyroidism
Case 5.4 IL-2 treatment and rheumatoid arthritis
Case 5.5 Fungal infections, fits and hypocalcaemia
Case 5.6 Lymphocyte-depleting monoclonal antibody treatments for multiple sclerosis and Graves’ disease
Case 5.7 Guillain–Barré syndrome
Case 5.8 Minocycline-induced systemic lupus erythematosus

Chapter 6: Lymphoproliferative Disorders
Case 6.1 Acute leukaemia (common type)
Case 6.2 Chronic lymphocytic leukaemia
Case 6.3 Sézary syndrome
Case 6.4 Hairy cell leukaemia
Case 6.5 Hodgkin's disease
Case 6.6 Non-Hodgkin's lymphoma
Case 6.7 Multiple myeloma
Case 6.8 Benign paraproteinaemia
Case 6.9 Waldenströms macroglobulinaemia

Chapter 7: Immune Manipulation
Case 7.1 Epstein-Barr virus-induced lymphoma in a transplant recipient
Case 7.2 Pneumocystis pneumonia complicating immunosuppressive therapy
Case 7.3 Severe rheumatoid arthritis treated with anti-tumour necrosis factor alpha antibodies
Case 7.4 Kawasaki's disease treated with intravenous immunoglobulin
Case 7.5 Fatal pneumococcal sepsis 8 years following splenectomy

Chapter 8: Transplantation
Case 8.1 Acute rejection
Case 8.2 Primary cytomegalovirus infection in a renal transplant recipient
Case 8.3 Bone marrow transplantation for acute myeloid leukaemia
Case 8.4 Graft-versus-host disease in an infant with severe combined immune deficiency

Chapter 9: Kidney Diseases
Case 9.1 IgA nephropathy
Case 9.2 Henoch–Schönlein nephritis
Case 9.3 Post streptococcal glomerulonephritis
Case 9.4 Membranoproliferative glomerulonephritis—type II
Case 9.5 Anti-glomerular basement membrane glomerulonephritis
Case 9.6 Antineutrophil cytoplasmic antibody-associated necrotizing crescentic glomerulonephritis
Case 9.7 Minimal-change nephropathy
Case 9.8 Membranous glomerulonephritis
Case 9.9 Idiopathic AL amyloid
Case 9.10 Acute tubulointerstitial nephritis
Case 9.11 Myeloma kidney

Chapter 10: Joints and Muscles
Case 10.1 Septic arthritis
Case 10.2 Rheumatoid arthritis
Case 10.3 Fibrosing alveolitis in rheumatoid arthritis
Case 10.4 Ankylosing spondylitis
Case 10.5 Reiter's disease
Case 10.6 Behçet's syndrome
Case 10.7 Juvenile chronic arthritis
Case 10.8 Systemic lupus erythematosus
Case 10.9 Mild systemic lupus erythematosus
Case 10.10 Mixed connective tissue disease
Case 10.11 Sjögren's syndrome
Case 10.12 Polyarteritis nodosa
Case 10.13 Polymyalgia rheumatica
Case 10.14 Polymyositis

Chapter 11: Skin Diseases
Case 11.1 Recurrent cold sores
Case 11.2 Nickel dermatitis
Case 11.3 Atopic eczema
Case 11.4 Atopic eczema
Case 11.5 Pemphigus vulgaris
Case 11.6 Hereditary angioedema
Case 11.7 Urticarial vasculitis
Case 11.8 Mixed cryoglobulinaemia
Case 11.9 Sub-acute cutaneous lupus erythematosus
Case 11.10 Systemic sclerosis

Chapter 12: Eye Diseases
Case 12.1 Conjunctival infection
Case 12.2 Allergic conjunctivitis
Case 12.3 Atopic keratoconjunctivitis
Case 12.4 Stevens–Johnson syndrome
Case 12.5 Behcet’s disease
Case 12.6 Lens-induced uveitis
Case 12.7 Reiter’s disease

Chapter 13: Chest Diseases
Case 13.1 Pneumonia and chronic lymphatic leukaemia
Case 13.2 Pulmonary tuberculosis
Case 13.3 Sarcoidosis
Case 13.4 Allergic bronchopulmonary aspergillosis
Case 13.5 Extrinsic allergic alveolitis: farmers' lung
Case 13.6 Extrinsic allergic alveolitis: bird fanciers' lung
Case 13.7 Cryptogenic fibrosing alveolitis
Case 13.8 Kawasaki's disease
Case 13.9 Takayasu's arteritis
Chapter 14: Gastrointestinal and Liver Diseases
Case 14.1 Pernicious anaemia
Case 14.2 Coeliac disease
Case 14.3 Crohn's disease
Case 14.4 Hepatitis A
Case 14.5 Hepatitis C-induced liver disease
Case 14.6 Autoimmune hepatitis
Case 14.7 Primary biliary cirrhosis
Case 14.8 Acquired immune deficiency syndrome presenting as Salmonella enteritis

Chapter 15: Endocrinology and Diabetes
Case 15.1 Graves' disease
Case 15.2 Hashimoto's thyroiditis
Case 15.3 Primary myxoedema
Case 15.4 Diabetes mellitus
Case 15.5 Addison's disease
Case 15.6 Autoimmune male infertility
Case 15.7 Autoimmune polyendocrinopathy

Chapter 16: Haematological Diseases
Case 16.1 Primary autoimmune haemolytic anaemia
Case 16.2 Cold haemagglutinin disease
Case 16.3 Cephalosporin-induced haemolytic anaemia
Case 16.4 Immune thrombocytopenia
Case 16.5 Neonatal alloimmune diseases
Case 16.6 Primary antiphospholipid antibody syndrome
Case 16.7 Transmission of hepatitis C by a blood product

Chapter 17: Neuroimmunology
Case 17.1 Haemophilus influenzae type b meningitis
Case 17.2 Multiple sclerosis
Case 17.3 Myasthenia gravis
Case 17.4 Guillain-Barré syndrome
Case 17.5 Chronic inflammatory peripheral neuropathy
Case 17.6 Systemic lupus erythematosus

Chapter 18: Pregnancy
Case 18.1 A mother infected with Listeria
Case 18.2 Hypogammaglobulinaemia of prematurity
Case 18.3 Recurrent spontaneous abortion
Case 18.4 Systemic lupus erythematosus
Case 18.5 Transient neonatal Graves’ disease
Case 18.6 Haemolytic disease of the newborn

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